infective endocarditis Queensland (ieQ)

ieQ logoieQ is a Prince Charles Hospital initiative to establish Australia’s first clinical and research collaborative supporting improved outcomes for patients with infective endocarditis.

Established in 2017, and facilitated by a Metro North SEED Grant and extensive clinician in-kind support, the collaborative has established a multi-faceted structural platform. In May 2018, the Collaborative received additional recognition and support from The Prince Charles Hospital Foundation “The Common Good”.

Affiliations

UQ logo

Pathology QLD logo

QLD Government logo

Supported by

The Common Good logo

 

LINK and SEED Innovation Funding
Clinical Operations & Strategic Implementation (COSI); Metro North Hospital and Health Service       

                  

About

Why?

Infective Endocarditis [IE] is a relatively uncommon condition in general practice, but is more common in cardiothoracic referral hospitals such as The Prince Charles Hospital. This condition affects dozens of Queenslanders per year, many requiring open-heart surgery. At least 1 in 10 Queenslanders with this disease will die from it and many more will suffer serious consequences affecting their quality of life. At TPCH, we admit and treat an estimated 60-80 patients with infective endocarditis every year.

Because of the relative rarity of this condition, little is actually known about it. All current guidelines are international, and none specific to Australia. Our leads, representing TPCH, are part of a global effort to expand knowledge about this condition.

How?

  • Under a clinical and research framework, ieQ aims to improve understanding, in an Australian context, of this disease.
  • By having an established expert working group across multiple disciplines, with an affiliated patient/consumer representative, we’ll optimise education, research and translational opportunities.
  • With a focus on parallel clinical engagement and provision of an Expert Advisory Team [initially localised to TPCH but planned to expand state-wide], we can support front-line, evidenced-based, patient care.
  • The enabling of the IE Registry and Biobank [HREC/15/QPCH/60] is the first of its kind in Australia, and is anticipated to provide a strong repository for a broad spectrum of future research endeavours, from biomarkers through to genetics, and epidemiology through to health service utilisation.

Download the ieQ flyer

Structure

ieQ structure

 

Our people

Chair:
Dr Robert Horvath MBBS FRACP FRCPA   
Infectious Diseases Physician and Clinical Microbiologist;
Infection Management services; The Prince Charles Hospital
 
Co-chair: (academic)
Dr John F Sedgwick MBBS FRACP FCSANZ FASE
Cardiologist and Senior Staff Specialist (honorary), The Prince Charles Hospital
 
 
Co-chair : (TPCH)
 Dr Yong S Wee MBBS FRACP
 Cardiologist, The Prince Charles Hospital
 
 
 
 

Management and Governance Committee:

Dr Robert Horvath MBBS FRACP FRCPA                                                                     

Dr John F Sedgwick MBBS FRACP FCSANZ FASE

Dr Yong S Wee MBBS FRACP

Dr Joseph C Lee  FRACP
Clinical Director and Specialist Consultant Physician; Nuclear Medicine; Department of Medical Imaging; The Prince Charles Hospital
 

 Dr David B Godbolt MBBS B.Med Sci FRCPA. Consultant Anatomical Pathologist.

 Director of Pathology, The Prince Charles Hospital Group.

 

Dr Peter Pohlner MBBS FRACS. Cardiac Surgeon. The Prince Charles Hospital.

 

 

Dr Alaa Alghamry MB BCh FRACP
General Medicine and Stroke Physician. Internal Medicine.
The Prince Charles Hospital

 
Project Manager:

Ms Dionne Essenstam

 

Infective Endocarditis Working Group:

Terms of Reference with current membership as of April 2018

 

Clinical guidelines and links

Australasian Society for Infectious Diseases

The Australasian Society for Infectious Diseases is the peak professional body for infectious diseases and microbiology in the region and a key stakeholder for government departments, medical colleges and other societies, including international organisations. Membership encompasses Infectious Diseases Physicians, Clinical Microbiologists, Scientists, Infection Control Practitioners, Public Health Physicians, Sexual Health Physicians, Veterinarians and others eminent in the field of infectious diseases. The aims of the society are to:

  • Advance postgraduate education in infectious diseases in Australasia and internationally;
  • Promote research in all aspects of infectious diseases; and
  • Advocate for sound and evidence-based public health policy in matters related to infectious diseases.

Cardiac Soicety of Australia and New Zealand

The Society was constituted with the objective of promoting the highest standards of education, training, research and practice in cardiovascular medicine and surgery through:

a. contributing to the advancement of knowledge of the cardiovascular system and treatment of diseases

b. establishing and supporting the maintenance of professional and ethical standards of practice 

c. facilitation of the education of trainees in cardiovascular medicine 

d. facilitation of continuing professional development in cardiovascular medicine 

e. promotion and defence of equitable access of all Australians and New Zealanders to high quality cardiovascular healthcare; and 

f. promotion of good fellowship among those whose primary interest is the practice of cardiovascular medicine or surgery or allied subjects.

International Society of Cardiovascular Infectious Diseases

ISCVID was founded in the late 1980s to bring scientific awareness to endocarditis, a disease of high morbidity and mortality but with very little organized multinational collaboration. In the early 1990s this society began holding biennial scientific sessions to bring together the community of endocarditis investigators.

American Heart Association

The American Heart Association is the nation’s oldest and largest voluntary organization dedicated to fighting heart disease and stroke. Founded by six cardiologists in 1924, the AHA now includes more than 22.5 million volunteers and supporters. The AHA funds innovative research, fights for stronger public health policies, and provides critical tools and information to save and improve lives.
 Centre for Disease Control and Prevention      

The CDC works 24/7 to protect America from health, safety and security threats, both foreign and in the U.S. Whether diseases start at home or abroad, are chronic or acute, curable or preventable, human error or deliberate attack, CDC fights disease and supports communities and citizens to do the same.

As America's health protection agency, the CDC saves lives and protects people from health threats. To accomplish their  mission, the CDC conducts critical science and provides health information that protects against expensive and dangerous health threats, and responds when these arise.

Patient information

Leaflets for patients felt to have "endocarditis risk" hearts.

The diagnosis of "endocarditis risk heart " (higher risk than the average population) should only be made by a doctor.

The below document is an interim/draft document only.

A finalised version will be available here shortly.

Draft Patient Information Leaflet

Information for clinicians

The below document for clinicians detailing medical advice for possible endocarditis is a draft/interim document only.

A finalised version will be available here in the near future.

TheDraft Clinician Information Leaflet

ieQ projects

Ethically approved and current status:

HREC/16/QPCH/315: "Invasive Candidiasis – Experience over the Last Decade". Completed
HREC/15/QPCH/182: "A 15 year review of Coxiella burnetiid infective endocardititis in a tertiary cardiac centre in Queensland, Australia.". Completed
HREC/16/QPCH/351: "The Queensland Staphylococcus Lugdunensis Bacteraemia Audit". Finalising with publications in development.
HREC/15/QPCH/60: "Host Pathogen Relationships and improved diagnosis in Infective Endocarditis (IE)". Commencing soon.
HREC/17/QPCH/469: "The Queensland Staphylococcus Lugdunensis statewide molecular study".  On hold protem: scheduled to commence 2019.

Under ethics review:

HREC#tbc: "A multidisciplinary review of patients with Candidaemia and their outcomes; opportunities to improve health outcomes and service delivery".

Planned submissions (2019):

HREC#tbc: Draft title "Q-Fever: a statewide review of patients with affilliated endocarditis".
HREC#tbc: Draft title "The Queensland HACEK bacteraemia audit". 

 

Conference and Meeting Abstracts

2018

Australasian Society for Infectious Diseases: 10-12 May, Gold Coast

 

Cardiac Society of Australia and New Zealand: 66th ASM 2-5 Aug, Brisbane

 

18th International Symposium on Staphylococci and Staphylococcal Infections: 23 - 26 August 2018, Copenhagen, Denmark.  

 

15th International Society for CardioVascular Infectious Diseases (ISCVID) : 2-4 June 2019, Lausanne, Switzerland.

 

Publications

2018

Bookchapter

John F. Sedgwick and Gregory M. Scalia (September 12th 2018). The Role of Modern-Era Echocardiography in Identification of Cardiac Risk Factors for Infective Endocarditis, Advanced Concepts in Endocarditis. Michael S. Firstenberg, IntechOpen, DOI: 10.5772/intechopen.75760. Available from: "http://www.intechopen.com/embed/advanced-concepts-in-endocarditis/the-role-of-modern-era-echocardiography-in-identification-of-cardiac-risk-factors-for-infective-endo" />

Journal articles

Mark R. Armstrong, Kate L. McCarthy & Robert L. Horvath (2018): A contemporary 16-year review of Coxiella burnetii infective endocarditis in a tertiary cardiac center in Queensland, Australia, Infectious Diseases, DOI: 10.1080/23744235.2018.1445279

2016

Bookchapter

J.F. Sedgwick and G.M. Scalia (Nov 2016): Advanced Echocardiography for the Diagnosis and Management of Infective Endocarditis. In: Contemporary Challenges in Endocarditis (Open Access Online), INTECH, pp. 59-94.

 

News and events


RESEARCH GRANT CEREMONY June1 2018

Project Development Grant Recipient: infective endocarditis Queensland Collaborative

L to R : Dr Kayla Trahn, Dr John Sedgwick, Dr Peter Pohlner, Dr Robert Horvath, Dr Yong Wee, Ms Anne Cameron

 

November 2018

"Best of Grand Rounds"  winner Kanthi Vemuri.

Dr Kanthi Vemuri won "best of Grand Rounds" at The Prince Charles Hospital for her ieQ project "Staphylococcus.lugdunensis Bacteraemia in Queensland- a State-wide audit"

December 2018

Farewell Anne Cameron.

Sadly we farewell Anne who was our unaugural project manager initially funded from a Metro-North Seed-Link grant.

Her experience with prior research efforts was a huge benefit when organising the ethics submissions for our Biobank and audits.Amongst her many endeavours, Anne initiated our website and assisted with our Lugdunensis and Candidaemia projects. Her efforts assisted our innovation from being a "thought bubble" to being a real innovation.

Thank you Anne!

 

April 2019

 

Welcome Dionne Essenstam.

Dionne joined us as our 2nd Project Manager, with prior experinces at Queensland Childrens Hospital and Royal Brisbane and Women's Hospital (where she still works as a Nursing Director).

Welcome Dionne!

 

June 2019

ISCVID

ieQ was honoured at having 10 abstracts (from 3 ieQ sites) selected for presentation at the bi-annual ISCVID conference at Lausanne, Switzerland. ieQ  also presented two orals.

In addition, the overall Australasian contingent was the largest since ISCVID Cairns, (in other words,the largest for an ISCVID conference not held in Australasia) demonstrating an increased interest in this condition in Australasia.

Abstracts now available

October 2019

Pre-Symposium Lecture at TPCH by Professor David Durack.

Friday October 25th 0730.

Prof David Durack delivered a speech on "the Past Present and Future of Endocarditis Prophylaxis" at the Cardiology Grand Rounds at TPCH.

On the biggining of a momentous week, the TPCH Endocarditis Database and Biobank received SSA approval this same day!

Saturday October  26th

Endocarditis Symposium.

For details see symposium page.

A hugely successful day, hopefully fostering new collaborations in endocarditis research in Australia, and future meetings.

We wish to take this opportunity to thank all those who made this day a sucess: in no particular order, the sponsors, MSD, TPCH and The Common Good Foundation, the various societies who helped advertise it , ASID (special thanks to he ozbug group email system) , CSANZ, ANZSiCS, RCPA, RACP, TPCH for providing the venue, the organising committee for all their pain-taking work, the speakers (especially the invited speakers who helped plan the program) and all who attended!

Tuesday October 29th

1st patient enrolled in database/biobank.

Wednesday October 30th

1st specimens biobanked!


Picture: Rebecca Watkin of Pathology Queensland processing first biobanking specimens.

2nd patient enrolled in biobank/database.

Thursday October 31

2nd specimens biobanked.

In recognition of these momentous events during October, ieQ will dedicate October of each year to national collaborative functions.

Friday November 1st 2019

Unique Patron system inaugurated.

ieQ is commencing a system of International (based outside of Australasia) and Australasian (based outside of Queensland) patrons to help guide ieQ from non-Queensland perspectives. Over several years of recruitment we hope to have several patrons in each tier, one of each specialty to reflect the multidisciplinary structure of ieQ.

We welcome our 1st patrons (and are hounoured by their quick acceptance of our invitations!)

1st International Patron Professor David Durack.

1st Australasian patrons Professor Eugene Athan and Doctor Nathan Dwyer.

Welcome!

Thursday Nov 21

1st expansion of biobank announced.

Sunshine Coast University Hospital, Rockhampton Hospital and Townsville Hospital have volunteered to be the test-sites for for 1st biobank expansion (which seques into next news item).  Thank you Shradha, Rudyard, Kim and Chris!

Thursday November 28

1st IE data-field synchronisation meeting announced (for Dec 12th)

To help with future IE collaborations, ieQ is hosting discussions on synchronisation of data-fields.

See collaborations subsection of networking page for details

 

 

 

Disclaimer

The views expressed on this website are the views of ieQ members and are not necessarily the views of UQ or Queensland Health.