Field:

  • Biomedical engineering
  • Neuroscience
  • Radiology and imaging

Location: Queensland Brain Institute

Type of student: Both PhD/MPhil and Volunteer

Type of work: 

  • Literature review
  • Secondary data analysis
  • Statistical analysis
  • Wet lab work

Neurodegenerative diseases, such as dementia, are irreversible and generally incurable and hence early detection is essential so that interventions can be applied to slow down its progression. Various diseases have been found to affect brain connectivity in disease-specific pattern, however the mechanisms are still unclear. We focused on characterising the change of brain connectome using MRI techniques for mapping structural and functional connectivity in mouse models and humans in vivo. This project will evaluate the effects of disease-associated risk genes or treatments on the brain connectome in transgenic mouse models of neurodegenerative diseases, such as Alzheimer’s disease, Huntington disease, frontotemporal dementia and amyotrophic lateral sclerosis, to improve our understanding of the genetic effects on the pathogenesis in human.

Visit the Functional and molecular neuroimaging lab webpage

Supervisor

Associate Professor Kai-Hsiang Chuang

Associate Professor Kai-Hsiang Chuang

Principal Research Fellow
Queensland Brain Institute