Field: Health services

Location: UQ Centre for Clinical Research (Herston)

Type of student: Both types will be considered (i.e. you are flexible with your project/s)

Type of work:

  • Literature review 
  • Qualitative methods 

Brief synopsis:

Background: N‐of‐1 trials are randomised controlled trials of treatment versus a placebo (or another treatment) within an individual patient to determine individual response to treatment (please click here for futher information and examples). N-of-1 trials provide the highest level of evidence for making treatment decisions for individual patients. Despite this, previous research has identified potential barriers to the uptake of n-of-1 trials in clinical practice. This study aims to explore clinician and patient perspectives about the use of n-of-1 trials in clinical practice.

Methods: Two* online, theory-based surveys will be developed to explore (1) clinicians' views in relation to conducting n-of-1 trials in clinical practice and (2) patients' views in relation to participating in n-of-1 trials in clinical practice. The questionnaire items in both online surveys will be based on the Theoretical Domains Framework (TDF; Michie et al., 2005). The TDF provides a broad and inclusive approach to understanding theory-based predictors of clinical and health-related behaviour. The TDF was developed by an expert consensus group, which reviewed 33 behavioural theories and their associated 128 theoretical constructs, identifying 12 theoretical domains based on commonalities between constructs. The TDF broadly covers all scientific explanations of behaviour based on current theorising and has been used widely to understand the perceptions and behaviours of clinicians and patients. Data from the project will be analysed quantitatively. The survey results will provide important insights about potential barriers and facilitators in relation to the uptake of n-of-1 trials in clinical practice.

Learning objectives: The students will learn about a novel research method; N-of-1 methods play a key role in the movement towards personalised medicine, shared-decision-making and patient-centred healthcare. Students will gain experience in developing and analysing survey research. *One student will work on the clinician survey and one student will work on the patient survey.

Prerequisite skills: N/A

Time frame:N/A



Dr Jane Nikles

Dr Jane Nikles

Senior Research Fellow
UQ Centre for Clinical Research

Contact Person

Dr Suzanne McDonald

Senior Research Technician
UQ Centre for Clinical Research