Field: Cancers, Endocrinology, Immunology, Rheumatolog

Location: Princess Alexandra Hospital

Type of student: Both types will be considered (i.e. you are flexible with your project/s) 

Type of work: Chart reviews, Clinical work, Literature review, Statistical analysis 

Brief synopsis

This project will investigate autoimmune disease outcomes of checkpoint inhibitor immunotherapy at PA Hospital. Initially we will identify, from the Oncology team’s chemo and immunotherapy treatment database, all patients who have received immunotherapy. Other medications taken by these patients are recorded in the database, which will help to initially flag patients who may have developed thyroiditis, hypophysitis, T1D, RA, PMR, colitis. Next we will interrogate the iEMR record of all immunotherapy patients to ascertain all who developed autoimmune disease, and/or autoantibodies and to create a database of clinical and lab data. This will require a LNR ethics through Metro South HREC. From the data we will investigate laboratory evidence e.g. autoantibodies, treatment, clinical departments involved and outcomes of autoimmune disease and cancer. We will compile the findings into a report, to be presented to a meeting of involved clinical teams. We aim to develop an integrated model of care so that development of autoimmune disease will in the future be rapidly diagnosed and well managed in a multi-disciplinary clinic setting, in which patients and clinicians are also engaged in research to better understand and manage autoimmune complications.

Prerequisite skills: None

Time frameAvailable immediately until end of 2019

Website: https://www.ncbi.nlm.nih.gov/pubmed/29516216; https://www.ncbi.nlm.nih.gov/pubmed/27539666

Supervisor

Associate Professor Anthony Russell

Director of Endocrinology
Princess Alexandra Hospital

Project Contact

Dr Matthew Terrill

Clinical Academic Registrar
Princess Alexandra Hospital Southside Clinical Unit