Dr Julia Pagan
Lecturer
Faculty of Medicine
School of Biomedical Sciences
| Featured projects | Duration |
|---|---|
| Multiple projects in molecular and cell biology related to cancer research | |
| Role of Cep55 in ovarian cancer |
Book Chapter
Pagan, Julia, Bolderson, Emma, Jones, Mathew and Khanna, Kum Kum (2009). Chromatin modifications involved in the DNA damage response to double strand breaks. DNA damage response: implications on cancer formation and treatment. (pp. 109-131) edited by Kum Kum Khanna and Yosef Shiloh. New York, NY, United States: Springer. doi: 10.1007/978-90-481-2561-6_6
Journal Articles
Ng, Dominic C.H., Richards, Dominic K., Mills, Richard J., Ho, Uda Y., Perks, Hannah L., Tucker, Callum R., Voges, Holly K., Pagan, Julia K. and Hudson, James E. (2020). Centrosome reduction promotes terminal differentiation of human cardiomyocytes. Stem Cell Reports, 15 (4), 817-826. doi: 10.1016/j.stemcr.2020.08.007
Rona, Gergely, Roberti, Domenico, Yin, Yandong, Pagan, Julia K., Homer, Harrison, Sassani, Elizabeth, Zeke, Andras, Busino, Luca, Rothenberg, Eli and Pagano, Michele (2018). PARP1-dependent recruitment of the FBXL10-RNF68-RNF2 ubiquitin ligase to sites of DNA damage controls H2A.Z loading. eLife, 7 e38771. doi: 10.7554/eLife.38771.001
Kuchay, Shafi, Giorgi, Carlotta, Simoneschi, Daniele, Pagan, Julia, Missiroli, Sonia, Saraf, Anita, Florens, Laurence, Washburn, Michael P., Collazo-Lorduy, Ana, Castillo-Martin, Mireia, Cordon-Cardo, Carlos, Sebti, Said M., Pinton, Paolo and Pagano, Michele (2017). PTEN counteracts FBXL2 to promote IP3R3-and Ca2+-mediated apoptosis limiting tumour growth. Nature, 546 (7659), 554-558. doi: 10.1038/nature22965
Pagan, Julia K., Marzio, Antonio, Jones, Mathew J. K., Saraf, Anita, Jallepalli, Prasad V., Florens, Laurence, Washburn, Michael P. and Pagano, Michele (2015). Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing. Nature Cell Biology, 17 (1), 31-43. doi: 10.1038/ncb3076
Skaar, Jeffrey R., Pagan, Julia K. and Pagano, Michele (2014). SCF ubiquitin ligase-targeted therapies. Nature Reviews Drug Discovery, 13 (12), 889-903. doi: 10.1038/nrd4432
Skaar, Jeffrey R., Pagan, Julia K. and Pagano, Michele (2013). Mechanisms and function of substrate recruitment by F-box proteins. Nature Reviews Molecular Cell Biology, 14 (6), 369-381. doi: 10.1038/nrm3582
Pagan, Julia, Seto, Tiffany, Pagano, Michele and Cittadini, Antonio (2013). Role of the ubiquitin proteasome system in the heart. Circulation Research, 112 (7), 1046-1058. doi: 10.1161/CIRCRESAHA.112.300521
Duan, Shanshan, Cermak, Lukas, Pagan, Julia K., Rossi, Mario, Martinengo, Cinzia, di Celle, Paola Francia, Chapuy, Bjoern, Shipp, Margaret, Chiarle, Roberto and Pagano, Michele (2012). FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas. Nature, 481 (7379), 90-94. doi: 10.1038/nature10688
Pagan, Julia and Pagano, Michele (2011). FBXW5 controls centrosome number. Nature Cell Biology, 13 (8), 888-890. doi: 10.1038/ncb2312
Bashir, Tarig, Pagan, Julia K., Busino, Luca and Pagano, Michele (2010). Phosphorylation of Ser72 is dispensable for Skp2 assembly into an active SCF ubiquitin ligase and its subcellular localization. Cell Cycle, 9 (5), 971-974. doi: 10.4161/cc.9.5.10914
Skaar, Jeffrey R., D'Angiolella, Vincenzo, Pagan, Julia K. and Pagano, Michele (2009). SnapShot: F Box Proteins II. Cell, 137 (7), 1358-U100. doi: 10.1016/j.cell.2009.05.040
Arun Gupta, Qin Yang, Raj K. Pandita, Clayton R. Hunt, Tao Xiang, Sandeep Misri, Sicong Zeng, Julia Pagan, Jessie Jeffery, Janusz Puc, Rakesh Kumar, Zhihui Feng, Simon N. Powell, Audesh Bhat, Tomoko Yaguchi, Renu Wadhwa, Sunil C. Kaul, Ramon Parsons, Kum Kum Khanna and Tej K. Pandita (2009). Cell cycle checkpoint defects contribute to genomic instability in PTEN deficient cells independent of DNA DSB repair. Cell Cycle, 8 (14), 2198-2210. doi: 10.4161/cc.8.14.8947
Skaar, Jeffrey R., Pagan, Julia K. and Pagano, Michele (2009). SnapShot: F Box Proteins I. Cell, 137 (6), 1358-U100. doi: 10.1016/j.cell.2009.05.039
Pagan, Julia K., Arnold, Jeremy, Hanchard, Kim J., Kumar, Raman, Bruno, Tiziana, Jones, Mathew J.K., Richard, Derek J., Forrest, Alistair, Spurdle, Amanda, Verdin, Eric, Crossley, Merlin, Fanciulli, Maurizio, Chenevix-Trench, Georgia, Young, David B. and Khanna, Kum Kum (2007). A novel corepressor, BCoR-L1, represses transcription through an interaction with CtBP. Journal of Biological Chemistry, 282 (20), 15248-15257. doi: 10.1074/jbc.M700246200
Kay, J. G., Murray, R. Z., Pagan, J. K. and Stow, J. L. (2006). Cytokine secretion via cholesterol-rich lipid raft-associated SNAREs at the phagocytic cup. Journal of Biological Chemistry, 281 (17), 11949-11954. doi: 10.1074/jbc.M600857200
Pagan, J. K., Wylie, F. G., Joseph, S. R., Widberg, C., Bryant, N. J., James, D. E. and Stow, J. L. (2003). The t-SNARE syntaxin 4 is regulated during macrophage activation to function in membrane traffic and cytokine secretion. Current Biology, 13 (2), 156-160. doi: 10.1016/S0960-9822(03)00006-X
Shurety, Wenda, Pagan, Julia K., Prins, Johannes B. and Stow, Jennifer L. (2001). Endocytosis of uncleaved tumor necrosis factor-alpha in macrophages. Laboratory Investigation, 81 (1), 107-117. doi: 10.1038/labinvest.3780216
Conference Paper
Pagan, J. K., Wylie, F. G. and Stow, J. L. (2002). Regulation of TNF trafficking in macrophages. 42nd Annual Meeting of the American-Society-for-Cell-Biology, San Francisco California, 14-18 December 2002. Bethesda, MD United States: American Society for Cell Biology.