Isaac completed a Bachelor of Pharmacy, with a major in clinical and experimental therapeutics in 2017, and since started his Medical degree in 2019.

Isaac is completing an intercalated MD/PhD with the Queensland Brain Institute under the supervision of Professor Jürgen Götz and Dr Liviu Bodea.

Isaac’s project will investigate the mechanisms by which microglia internalise tau protein, a pathognomonic lesion found in the brains of Alzheimer’s patients that impedes neuronal function. Microglia are the innate immune cells within the brain responsible for maintaining parenchymal homeostasis, but in Alzheimer’s disease these cells appear to lose their homeostatic function.

This project aims to characterise tau internalisation pathways in microglia, with a secondary focus on how tau internalisation impacts microglial metabolic function.